喵咪社区

Fibromyalgia is a heterogenous primary pain syndrome whose severity has been associated with descending pain modulatory system (DPMS) function and functional connectivity (FC) between pain processing areas. The brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism has been linked to vulnerability to chronic pain. In this cross-sectional imaging genetics study, we investigated fibromyalgia, the relationship between BDNF Val66Met heterozygous genotypes (Val/Met), and the functional connectivity (FC) response pattern to acute pain stimulus in the motor (MC) and prefrontal (PFC) cortex assessed by near-infrared spectroscopy (fNIRS) before and after a cold pressor test utilizing water (0-1聽掳C). Also, we assessed the relationship between this genotype with the DPMS function and quality of life. We included 42 women (Val/Val鈥�=鈥�30; Val/Met鈥�=鈥�12) with fibromyalgia, ages 18-65. The MANCOVA comparing Val/Met to Val/Val genotypes showed higher 螖FC between left(l)-PFC-l-MC (尾鈥�=鈥�0.357, p鈥�=鈥�0.048), l-PFC-right(r)-PFC (尾鈥�=鈥�0.249, p鈥�=鈥�0.012), l-PFC-r-MC (尾鈥�=鈥�0.226, p鈥�=鈥�0.022), and l-MC-r-PFC (尾鈥�=鈥�0.260, p鈥�=鈥�0.016). Val/Met genotypes showed higher efficiency of the DPMS and lower disability due to pain. Here we show that fibromyalgia patients carrying the Val/Met BDNF genotype presented an increased 螖FC across MC and PFC in response to acute pain associated with differences in acute pain perception and fibromyalgia symptoms.